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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described by their focus on practical aspects of design that include recruitment and consent, adherence and the use routinely available equipment.
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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be valid and lessen the chance of bias, is also necessary. However, too much heterogeneity can cause problems with the design of the trial.
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프라그마틱 불법 is known for its top-quality games and for offering an exceptional user experience. The software is available on mobile devices and in a variety of languages. It has established itself as one of the top casino gaming platforms despite its relative infancy. Wolves is one of the latest games which is a five-reel slot machine with a hefty RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually requested by practitioners and policymakers to inform their decisions. They can be used to determine the causal relationship between an intervention with its outcomes. However, they should not be used as a substitute for explanation trials.
The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they are an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis, and pragmatic trials that inform the practice and policy decisions. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the features of a practical trial which includes recruitment, design and delivery of the intervention, and the follow-up.
There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.